肥胖,胰岛素耐药性,牙和牙周炎:综合症框架
Lorena Lúcia Costa Ladeira1, Gustavo Giacomelli Nascimento2,3,4, Fábio Renato Manzolli Leite2,3
1Postgraduate Program of Dentistry, Federal University of Maranhão, São Luís 65085-580, MA, Brazil.
Nutrients
|August 26, 2023
概括
这项研究表明,青少年的社会经济不平等和行为风险有助于肥胖和口腔疾病,如牙和牙周炎. 这些情况,包括胰岛素耐药性,是相互关联的,这表明需要一种综合性方法.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 疾病综合学 疾病综合学
背景情况:
- 肥胖和胰岛素抵抗在青少年中越来越普遍.
- 牙和牙周炎是慢性口腔疾病的重要负担.
- 了解代谢和口腔疾病之间的综合性相互作用对于公共卫生干预至关重要.
研究的目的:
- 调查青少年肥胖症和胰岛素耐药性与牙和牙周炎的综合性分组.
- 探索社会经济不平等和行为风险因素 (吸烟,酒精,高糖消费) 的调解作用.
- 用基于人口的队列来分析这些关系.
主要方法:
- 利用来自巴西圣路易斯的RPS队列研究数据 (n=2515,年龄18-19岁).
- 采用结构方程建模来分析潜在变量:肥胖和胰岛素抵抗表型,慢性口腔疾病负担和行为风险因素.
- 测量口腔健康通过,在探测时出血,探测深度,临床附着水平和可见斑块指数.
主要成果:
- 社会经济不平等显著预测了更高的慢性口腔疾病负担 (SC=0.222,p<0.001).
- 行为风险因素与慢性口腔疾病负担增加有关 (SC=0.103,p=0.013).
- 肥胖与胰岛素耐药性表型 (SC=0.072,p<0.001) 和慢性口腔疾病负担 (SC=0.066,p=0.005) 有关,胰岛素耐药性表型和慢性口腔疾病负担 (SC=0.053,p=0.032) 有显著的关联.
结论:
- 青少年肥胖和糖尿病早期症状与牙损伤和牙周炎相结合.
- 这些发现支持一种综合性视角来理解和解决这些相互关联的健康问题.
- 针对社会经济因素和行为风险的干预措施对于预防青少年这种综合症至关重要.
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