乳清蛋白食补充剂:金属暴露评估和风险表征
Elena Bethencourt-Barbuzano1, Dailos González-Weller2, Soraya Paz-Montelongo1
1Interuniversity Group of Environmental Toxicology, Food and Drug Safety, University of La Laguna, 38071 La Laguna, Spain.
Nutrients
|August 26, 2023
概括
乳清蛋白补充剂含有必要的和潜在的有毒金属. 虽然适度摄入是安全的,但高摄入量可能超过某些矿物质的建议每日摄入量,造成潜在的健康风险.
科学领域:
- 食品科学 食品科学 食品科学
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
背景情况:
- 蛋白质补充剂,特别是乳清制品,是流行的饮食项目.
- 这些补充剂含有各种必需的和潜在的有毒矿物元素.
- 评估与这些元素相关的饮食暴露和健康风险至关重要.
研究的目的:
- 分析乳清蛋白补充剂中的矿物元素含量.
- 在不同的消费场景下评估饮食中对这些元素的暴露.
- 评估与长期消费相关的潜在健康风险.
主要方法:
- 分析了47个乳清蛋白补充剂样本,使用诱导合等离子体 - 光学发射光谱学 (ICP-OES).
- 对三个消费场景 (30g,60g,100g/天) 的饮食暴露的评估.
- 计算危险指数 (HI) 来确定健康风险.
主要成果:
- 在最高度中发现 (K) 和 (Ca).
- 适度摄入 (30g/天) 提供了 (Cr) 和 (Mo) 建议摄入量的显著百分比.
- 乳清蛋白补充剂的高消费 (100g/天) 可能导致超过每日推摄入的Cr, (Zn),铁 (Fe),Mo和 (Mg),造成潜在的风险.
结论:
- 25年来每天摄入30g,60g或100g的乳清蛋白补充剂并不构成健康风险,因为危险指数 (HI) 仍然低于1.
- (Co), (Mo) 和 (Cr) 是导致HI的主要基本元素.
- 建议包括改善消费者信息,产品标签和食补充剂的监管,以管理潜在的健康风险.
相关概念视频
01:26Toxic Reactions: Overview
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
01:23Toxicity Testing in Animals
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...