维生素D在心血管疾病中的作用
Man Hung1,2,3, Wendy C Birmingham4, Monica Ocampo1
1College of Dental Medicine, Roseman University of Health Sciences, 10894 S. River Front Parkway, South Jordan, UT 84095, USA.
Nutrients
|August 26, 2023
概括
低维生素D水平,特别是缺乏和不足,与心血管疾病 (CVD) 有关. 保持最佳的维生素D可以支持心血管健康.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是美国死亡的主要原因之一.
- 维生素D在心血管健康中的作用得到了广泛的研究,但仍然没有确定性.
- 血清25-基维生素D [25(OH) D]是维生素D状态的关键指标.
研究的目的:
- 调查报告的心血管疾病 (CVD) 与血清25-氧维生素D [25(OH) D]水平之间的关联.
- 分析与心脏病发病率相关的维生素D状态类别.
- 为预防心血管疾病提供潜在的维生素D补充策略的证据.
主要方法:
- 利用了来自2015-2018年国家健康和营养检查调查 (NHANES) 的数据,其中有9825名成年参与者.
- 定义CVD为中风,心脏病发作,心力衰竭或冠心病.
- 采用了奇平方测试,t测试和回归模型来分析维生素D水平与心血管疾病状态之间的关系.
主要成果:
- 维生素D缺乏 (<30nmol/L) 与心血管疾病有显著的关联 (AOR=1.48;95%CI=1.11-1.98;p<0.05).
- 维生素D缺乏 (30-49.9 nmol/L) 也与心血管疾病有显著的相关性 (AOR = 1.28;95% CI = 1.06-1.54;p < 0.05).
- 在充足的维生素D水平 (>125 nmol/L) 和报告的心血管疾病之间没有发现显著的关联.
结论:
- 维生素D缺乏和不足与心血管疾病风险增加有关.
- 医疗保健专业人员可能会考虑补充维生素D来改善心血管健康.
- 需要进一步的研究来确定因果关系和心血管疾病预防的最佳维生素D水平.
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