肠道微生物群和重症患者:免疫及其通过益生菌和免疫营养调节的免疫力
Ludovico Abenavoli1, Emidio Scarpellini2, Maria Rosaria Paravati1
1Department of Health Sciences, University "Magna Graecia", 88100 Catanzaro, Italy.
Nutrients
|August 26, 2023
概括
危急病患者的肠道功能失调会导致有害的炎症. 通过益生菌和免疫营养调节肠道微生物群,有望改善重症监护机构的结果.
科学领域:
- 关键护理医学 关键护理医学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 危急病患者表现出高炎症反应,导致组织损伤和器官衰竭.
- 肠道微生物群及其不平衡 (不平衡) 在启动和延续这种炎症级联中发挥着重要作用.
- 了解肠道微生物群功能障碍对于管理系统性炎症反应综合征 (SIRS) 和多器官功能障碍综合征 (MODS) 至关重要.
研究的目的:
- 审查当前关于危急病患者肠道微生物群组成的文献.
- 探索肠道失生症在严重疾病中的病理生理学作用.
- 讨论微生物群调节策略的潜力,包括益生菌和免疫营养,以改善患者的治疗结果.
主要方法:
- 关于在重症患者的肠道微生物群研究的文献综述.
- 分析关于肠道失生症对系统性炎症影响的证据.
- 检查针对肠道微生物群的治疗干预措施的研究.
主要成果:
- 肠道功能障碍在重症患者中很普遍,并导致全身炎症.
- 益生菌干预措施在减轻炎症和改善结果方面显示出初步的希望,特别是在术后感染和通风方面.
- 免疫营养是一个新兴的领域,有可能影响重症监护病人的健康状况.
结论:
- 肠道微生物群是重症患者炎症反应的关键因素.
- 通过益生菌和免疫营养准肠道微生物群是一个有希望的治疗途径.
- 需要进一步的研究,以充分阐明机制,并优化关键护理的干预措施.
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