脂肪组织皮化减弱了大鼠肥胖导致的骨质形成减少
Milene Subtil Ormanji1, Maria Victória Lazarini Melo1, Renata Meca1
1Nephrology Division, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.
Nutrients
|August 26, 2023
概括
消毒白色脂肪组织改善了肥胖大鼠的骨形成. 这表明脂肪组织-大脑-骨轴,特别是神经Y,在与肥胖有关的骨代谢变化中起着关键作用.
科学领域:
- 内分泌学 在内分泌学.
- 骨生物学 骨生物学 骨生物学
- 神经科学是一个神经科学.
背景情况:
- 肥胖对骨代谢的影响受到争论,关于其影响的报道相互矛盾.
- 中枢神经系统通过细胞因子,激素和神经调节剂影响骨重塑.
研究的目的:
- 为了研究双边 retroperitoneal 白脂肪组织 (rWAT) 脱皮 (Dnx) 对肥胖大鼠的骨代谢和重塑的影响.
- 阐明脂肪组织-大脑-骨轴在肥胖引起的骨改变中的作用.
主要方法:
- 雄性Wistar大鼠在18周内被食高脂肪饮食 (HFD) 或标准饮食 (SD).
- rWAT无核化 (Dnx) 或假手术是在第14周进行的.
- 分析包括生物化学,荷尔蒙,骨组织形态测量和组织基因/蛋白质表达.
主要成果:
- 养HFD的老鼠表现出骨质形成的减少,血清/骨质瘦素和FGF23的增加,血清和下丘脑中神经Y (NPY) 的增加,以及维生素D和PTH的减少.
- rWAT Dnx恢复了肥胖大鼠的骨形成标志物和组织形态测量.
- 血清和下丘脑NPY水平在Dnx后下降,但没有影响勒.
结论:
- 在肥胖的老鼠中,rWAT的消化增强了骨的形成.
- 这种改善主要是由于NPY的神经激素作用的减少而引起的.
- 这项研究强调了脂肪组织-大脑-骨轴在肥胖期间调节骨代谢中的重要性.
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