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相关概念视频

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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相关实验视频

Updated: Jun 22, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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脂肪组织皮化减弱了大鼠肥胖导致的骨质形成减少.

Milene Subtil Ormanji1, Maria Victória Lazarini Melo1, Renata Meca1

  • 1Nephrology Division, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.

Nutrients
|August 26, 2023
PubMed
概括
此摘要是机器生成的。

消毒白色脂肪组织改善了肥胖大鼠的骨形成. 这表明脂肪组织-大脑-骨轴,特别是神经Y,在与肥胖有关的骨代谢变化中起着关键作用.

关键词:
骨组织形态测量 骨组织形态测量 骨组织形态测量骨脂肪是指骨的脂肪.骨神经系统相互作用神经酸Y是神经酸Y的一种.

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科学领域:

  • 内分泌学 在内分泌学.
  • 骨生物学 骨生物学 骨生物学
  • 神经科学是一个神经科学.

背景情况:

  • 肥胖对骨代谢的影响受到争论,关于其影响的报道相互矛盾.
  • 中枢神经系统通过细胞因子,激素和神经调节剂影响骨重塑.

研究的目的:

  • 为了研究双边 retroperitoneal 白脂肪组织 (rWAT) 脱皮 (Dnx) 对肥胖大鼠的骨代谢和重塑的影响.
  • 阐明脂肪组织-大脑-骨轴在肥胖引起的骨改变中的作用.

主要方法:

  • 雄性Wistar大鼠在18周内被食高脂肪饮食 (HFD) 或标准饮食 (SD).
  • rWAT无核化 (Dnx) 或假手术是在第14周进行的.
  • 分析包括生物化学,荷尔蒙,骨组织形态测量和组织基因/蛋白质表达.

主要成果:

  • 养HFD的老鼠表现出骨质形成的减少,血清/骨质瘦素和FGF23的增加,血清和下丘脑中神经Y (NPY) 的增加,以及维生素D和PTH的减少.
  • rWAT Dnx恢复了肥胖大鼠的骨形成标志物和组织形态测量.
  • 血清和下丘脑NPY水平在Dnx后下降,但没有影响勒.

结论:

  • 在肥胖的老鼠中,rWAT的消化增强了骨的形成.
  • 这种改善主要是由于NPY的神经激素作用的减少而引起的.
  • 这项研究强调了脂肪组织-大脑-骨轴在肥胖期间调节骨代谢中的重要性.