在行为减肥期间,肥胖成年人的微生物组,表观基因组和饮食
Emily B Hill1, Iain R Konigsberg2, Diana Ir3
1Section of Nutrition, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Nutrients
|August 26, 2023
概括
这项研究探讨了减肥期间的肠道微生物组,表观基因组和饮食连接. 肠道微生物与代谢相关基因的DNA甲基化变化有关,为体重管理提供了洞察力.
科学领域:
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 肥胖是多因素的,涉及肠道微生物组,表观基因组和饮食.
- 在减肥干预期间这些因素之间的相互作用仍未得到充分研究.
研究的目的:
- 调查肠道微生物群 (MB),DNA甲基化 (DNAme) 和行为减肥计划之前和期间的饮食之间的关联.
主要方法:
- 成人 (n=47) 接受了为期3个月的减肥干预.
- 便MB通过16S测序分析;全血DNAme通过Infinium EPIC阵列.
- 通过7天记录评估的饮食摄入量和健康饮食指数 (HEI) 评分.
主要成果:
- 平均体重减轻量为6.2%.
- 特定的MB种类,如Ruminiclostridium和Akkermansia,与与细胞过程和新陈代谢相关的基因的DNAme有关.
- 与MB相关的DNAme与饮食因素之间没有发现显著的联系.
结论:
- 与粘素降解和SCFA产生相关的肠道微生物与表型相关基因的DNA甲基化相关.
- 这些发现提供了关于肠道MB变化如何影响减肥期间的新陈代谢的初步见解.
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