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克罗恩氏病患者的营养风险和萨科佩尼亚特征:与身体组成,身体表现,营养问卷和生物标志物的关系
Konstantinos Papadimitriou1, Paraskevi Detopoulou2, Konstantinos Soufleris3
1Faculty of Health and Rehabilitation Sciences, Metropolitan College of Thessaloniki, University of East London, 546 24 Thessaloniki, Greece.
克罗恩氏病患者没有出现肉症,但营养不良的风险仍然存在. 身体成分与炎症相关,突出了炎症和营养不良之间的相互作用,即使在缓解期.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 克罗恩氏病 (CD) 患者有营养不良的风险,这可能会加剧炎症并导致肉,对预后产生负面影响.
- 了解CD中营养不良和肉类的患病率对于改善患者的治疗结果和管理策略至关重要.
研究的目的:
- 评估克罗恩病患者营养不良和肉病的患病率.
- 研究CD患者的身体组成,炎症和营养状况之间的关系.
主要方法:
- 53名CD患者 (79%的缓解) 接受了身体组成,身体表现,营养状况 (使用MNA,MIRT,GLIM标准) 和生物标志物的评估.
- 使用SARC-F问卷和EWGSOP2标准评估了萨科佩尼亚,包括测量手握强度 (HGS),尾瘦质量 (ALM) 和步行速度.
- 主要成分分析被用来识别身体组成的模式及其与诸如C反应蛋白 (CRP) 等炎症标记物的关系.
主要成果:
- 根据不同的标准 (低BMI,CC,FFMI) 在5.6%至11.3%的患者中确定了营养不良.
- 没有患者符合肉类的标准,尽管有些人表现出低的手握强度 (7%) 和尾瘦质量 (14.8%).
- 高白蛋白和三肌皮折叠的模式与降低的C-反应性蛋白水平相关 (p=0.045),表明身体组成和炎症之间存在联系.
结论:
- 这项研究在评估的克罗恩病患者中没有发现肉类,尽管已经确定了营养不良的风险.
- 疾病患者的身体组成模式受到炎症负担的影响,这凸显了炎症和营养不良之间的复杂相互作用.
- 需要进一步的研究,特别是在老年人群和疾病恶化期间,以充分阐明CD-炎症-sarcopenia的关系.
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