蛋碳酸的水热转化为无毒素微纳米颗粒:细胞相容性和骨诱导性质
Adriana Torres-Mansilla1,2, Pedro Álvarez-Lloret1, Raquel Fernández-Penas2
1Departament of Geology, University of Oviedo, 33005 Oviedo, Spain.
Nanomaterials (Basel, Switzerland)
|August 26, 2023
概括
蛋转化为有价值的酸生物材料,使用一种新的一热水法. 这些酸盐纳米粒子是细胞相容的,促进骨细胞生长,为生物医学应用提供可持续的解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 材料化学 材料化学
- 生物矿物化 生物矿物化
背景情况:
- 蛋,主要是CaCO3石,含有有机基质.
- 将蛋废弃物转化为酸 (apatite) 纳米颗粒符合循环经济原则.
- 从蛋中合成阿帕纳米粒子的现有方法通常是多步骤的,涉及化.
研究的目的:
- 开发一种直接的,单的热水法,用于将蛋石转化为无情的微纳米颗粒.
- 研究表面处理 (NaClO) 对转化过程和由此产生的粒子形态学的影响.
- 评估合成的阿帕纳米颗粒的细胞相容性和骨质生成潜力.
主要方法:
- 在100-200°C的温度范围内采用了一式热水法.
- 使用了蛋颗粒 (<50微米),未经处理和先前处理NaClO.
- 酸 (K2HPO4) 被用作的来源,其度为P/CaCO3比率.
主要成果:
- 对于未经处理的蛋,在160°C达到完全转化为阿帕,产生六边形板颗粒.
- 对于经过NaClO处理的蛋,在180°C时发生了阿帕蒂特的形成,从而产生颗粒状 (球状) 的纳米粒子.
- 合成的阿帕微纳米颗粒与MG-63和m17.ASC细胞表现出细胞相容性.
- m17.ASC细胞的骨质分化是由阿帕纳米颗粒促进的.
结论:
- 直接的一热水法有效地将蛋废物转化为生物相容酸纳米颗粒.
- 该方法允许基于表面处理来控制粒子形态 (六角板与颗粒状球体).
- 由于它们的细胞相容性和骨诱导性质,这些阿帕纳米颗粒对骨组织工程和牙科有很大的前景.
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