在儿童和心律失常和缺血性心脏病中使用第一代抗胰岛素之间的关联:一个案例交叉研究
Ju Hee Kim1, Hye Ryeong Cha2, Eun Kyo Ha3
1Department of Pediatrics, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea.
Pharmaceuticals (Basel, Switzerland)
|August 26, 2023
概括
第一代抗组胺剂增加了儿童心血管事件的风险. 这项研究发现,在儿童群体中,它们的使用与心律失常和缺血性心脏病等事件之间存在显著的关联.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 药物监督 药物监督 药物监督
- 流行病学 流行病学
背景情况:
- 自20世纪90年代以来,第一代H1抗组胺药物的心脏毒性一直是争论的主题.
- 在一般儿科患者群体中进行的大规模研究很少.
- 现有研究尚未确定这些药物对儿童的心血管风险.
研究的目的:
- 在全国范围的儿科队列中调查第一代H1抗组胺剂和心血管事件的使用之间的关联.
- 提供关于这些常用于儿童的药物的安全性概况的强有力的证据.
- 量化与第一代抗胰岛素暴露相关的特定心血管事件的风险.
主要方法:
- 一项全国性的病例交叉研究,利用韩国国家医疗保险服务数据库 (2008-2012年出生) 的数据.
- 包括心血管事件的主要队列和排除特定先前存在的条件的第二队列.
- 条件后勤回归模型被用来估计几率比率 (ORs),比较危险期和控制期的暴露.
主要成果:
- 在使用第一代H1抗组胺剂的儿童中观察到心血管事件的风险增加 (调整的OR[aOR],1.201).
- 显著的关联在暴露后的10天和5天内持续存在 (aOR,1.25).
- 这些发现在主要和次要队列中一致,加强了观察到的关联.
结论:
- 第一代H1抗组胺的使用与儿童心血管事件的风险增加有关.
- 这项研究突出了关于在儿童群体中使用这些抗组胺剂的潜在安全问题.
- 进一步的研究和临床警是有必要的,以充分理解和减轻这些风险.
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