通过天然产品对结肠直肠癌的海斯顿修饰
Zijun Geng1, Meiqi Chen1, Qixuan Yu1
1School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China.
Pharmaceuticals (Basel, Switzerland)
|August 26, 2023
概括
自然产品通过向表观遗传机制来调节结直肠癌. 这篇评论探讨了黄素和白醇等化合物如何影响癌细胞生长,细胞灭绝和抗化疗.
科学领域:
- 在瘤学瘤学.
- 自然产品 化学 化学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 自然产品在结直肠癌 (CRC) 发病过程中至关重要,并充当基因调节剂.
- 它们通过多种信号通路影响CRC细胞生长,包括RAC1/PI3K/AKT,MAPK,Wnt/β-catenin,TGF-β,JAK-STAT,NF-κB,Notch,Hippo和Hedgehog.
研究的目的:
- 审查自然产品在结直肠癌中的表观遗传作用.
- 阐明它们对CRC细胞增殖,细胞亡,入侵,迁移和化学抵抗的影响.
- 为了解CRC的表观遗传学提供基础,并确定新的治疗点.
主要方法:
- 文献综述侧重于自然产品及其在结直肠癌中的表观遗传机制.
- 在癌症中通过天然产品调节的信号通路的分析.
- 检查特定化合物的作用,如白科丁D,金赛诺化物Rd和黄素对CRC进展的影响.
主要成果:
- 自然产品对结直肠癌细胞产生表观遗传作用.
- 化合物影响癌症的关键特征,包括扩散,亡,入侵和迁移.
- 自然产品显示出克服抗化疗耐药性的潜力.
结论:
- 自然产品为结直肠癌的预防和治疗提供了有希望的表观遗传策略.
- 了解这些机制可以导致新的治疗目标和改进CRC管理.
- 对自然产品表观遗传学的进一步研究对于推进CRC治疗至关重要.
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