诺基诺对中枢神经系统的抑郁和其他不良影响
Piotr Wierzbiński1, Joanna Hubska2, Michał Henzler2
1Psychiatry Outpatient Clinic, Okoniowa 5/33, 91-498 Łódź, Poland.
Pharmaceuticals (Basel, Switzerland)
|August 26, 2023
概括
诺基诺 (FQs) 是广泛使用的抗生素,与中枢神经系统 (CNS) 的副作用,如焦虑和抑郁症有关. 了解风险因素对于安全的FQ处方至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
背景情况:
- 诺基诺 (FQs) 是广泛的抗生素,在全球范围内处方率不断增加.
- 广泛使用导致报告的不良事件增加,特别是中枢神经系统 (CNS) 的影响.
- 美国食品和药物管理局在2016年发布了关于与FQ使用相关的显著精神病副作用的警告.
研究的目的:
- 为了提供一个结构化的中央神经系统 (CNS) 与诺基诺 (FQ) 使用相关的不良影响的综述.
- 总结有关FQ相关精神病学不良反应的最新发现.
- 为了突出FQ毒性的风险因素.
主要方法:
- 一个对68个选定的出版物的结构化审查.
- 分析报告中枢神经系统 (中枢神经系统) 的诺基诺 (FQ) 使用的不良影响.
主要成果:
- 对诺基诺 (FQs) 的精神病学不良反应发生在1-4.4%的患者中.
- 潜在的机制包括GABA受体的对抗性或与NMDA受体的相互作用.
- 风险因素包括老年患者,并发症和并发药物,尽管不良事件可以影响任何患者群体.
结论:
- 诺基诺 (FQ) 的使用与显著的中枢神经系统 (CNS) 副作用有关,包括精神疾病.
- 处方者必须了解诺 (FQ) 毒性的潜在风险和患者特异性风险因素.
- 对FQ诱导的中枢神经系统影响的精确机制进行进一步的研究是有必要的.
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