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Updated: Jul 18, 2025

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

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新型Anthranyl Phenylhydrazides的设计和合成:抗莱什曼活动和结构-活动关系

Claudia do Carmo Maquiaveli1, Edson Roberto da Silva1, Barbara Hild de Jesus1

  • 1Laboratório de Farmacologia e Bioquímica (LFBq), Departamento de Medicina Veterinária, Universidade de São Paulo Faculdade de Zootecnia e Engenharia de Alimentos, Av. Duque de Caxias Norte 225, Pirassununga 13635-900, SP, Brazil.

Pharmaceuticals (Basel, Switzerland)
|August 26, 2023
PubMed
概括

新的anthranyl phenylhydrazide衍生物在治疗被忽视的热带疾病莱什曼病方面表现有前途. 这些化合物对Leishmania寄生虫表现出强大的活性,为药物开发提供了潜在的新途径.

关键词:
莱什曼尼亚 (Leishmania) 是一种病.在 PTR1 中,PTR1 是乙烯基化物 乙烯基化物这是阿尔金纳.聚氨酸是多氨基的

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Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
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