Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Dual-Drug Nanocarrier Strategy for Ocular Fungal Infections: Micelles Embedded in Electrospun Nanofibers.

Molecules (Basel, Switzerland)·2026
Same author

Influence of Drying Methods on Redispersibility and Dissolution of Canagliflozin Nanocrystals: A Comparative Approach.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Development of Brimonidine-Loaded Ethosomes for Glaucoma: Investigation of Intraocular Pressure-Lowering Potential In Vivo.

Pharmaceutics·2026
Same author

Applications of Chitosan in Prevention and Treatment Strategies of Infectious Diseases.

Pharmaceutics·2024
Same author

Phytoactive Molecules and Nanodelivery Approaches for Breast Cancer Treatment: Current and Future Perspectives.

Current pharmaceutical biotechnology·2024
Same author

Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery.

Pharmaceuticals (Basel, Switzerland)·2024

相关实验视频

Updated: Jun 24, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.4K

基于聚合物和基的核酸输送系统.

Genada Sinani1, Meltem Ezgi Durgun2, Erdal Cevher2

  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Altinbas University, 34147 Istanbul, Türkiye.

Pharmaceutics
|August 26, 2023
PubMed
概括

聚合物微粒为输送核酸提供了一个有前途的解决方案,克服了稳定性差和细胞吸收等挑战,以提高各种疾病的治疗疗效.

关键词:
它们是DNA DNA DNA DNA.这是一个RNARNARNARNARNA.化聚合物中的聚合物.基因传递 基因传递 基因传递米塞尔的复杂性核酸核酸是一种核酸.多电离复合物米塞尔 (Micelle) 是一个复合物.聚合物米塞尔 (Micelle) 是一种聚合物.多重复合的多重复合体.

更多相关视频

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

10.8K
Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

23.2K

相关实验视频

Last Updated: Jun 24, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.4K
Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

10.8K
Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

23.2K

科学领域:

  • 生物技术和纳米医学
  • 基因治疗输送系统的基因治疗.

背景情况:

  • 核酸对疾病具有显著的治疗潜力,但面临着快速清除,不稳定性和细胞吸收不良等传递挑战.
  • 有效的传递系统对于克服这些障碍并实现所需的治疗结果至关重要.

研究的目的:

  • 审查聚合物微粒作为核酸的输送载体的设计,开发和应用.
  • 突出提高核酸输送,准和治疗疗效的策略.

主要方法:

  • 探索聚合物微粒结构,组成和制备方法.
  • 讨论策略,如刺激敏感组和带结合,以改善交付.
  • 分析核酸和化疗药物的同时输送,用于组合治疗.

主要成果:

  • 聚合物微粒在克服核酸输送的细胞外和细胞内障碍方面表现出多功能性.
  • 量身定制的微细胞设计可以保护核酸免受降解,并促进细胞吸收.
  • 通过细胞同时输送可使协同组合治疗成为可能.

结论:

  • 聚合物微粒是核酸治疗药物的有效载体,提高了安全性和有效性.
  • 先进的细胞策略解决了用于临床翻译的核酸输送的关键挑战.
  • 本综述提供了关于聚合物菌根基核酸输送的当前发展和未来方向的见解.