在行星滚筒融颗粒中材料运输特征
Tom Lang1, Andreas Bramböck2, Markus Thommes1
1Laboratory of Solids Process Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, Germany.
Pharmaceutics
|August 26, 2023
概括
星球滚筒融化颗粒处理 (PRMG) 提供减少灰尘并消除干燥步骤. 本研究研究了PRMG中的材料运输,这对于连续制造制药和提高产品质量至关重要.
科学领域:
- 制药技术 制药技术 制药技术
- 化学工程是化学工程的重要组成部分.
- 材料科学 材料科学 材料科学
背景情况:
- 化颗粒处理可以改善材料处理和颗粒大小分布.
- 药品的连续制造减少了质量波动.
- 行星滚筒颗粒机由于其设计和工艺控制,比双螺丝系统具有优势.
研究的目的:
- 为了研究行星滚筒化颗粒 (PRMG) 中的居住时间分布.
- 了解PRMG系统中的物料运输特性.
- 建立PRMG作为一个可行的连续制造方法在制药技术.
主要方法:
- 使用行星滚筒颗粒器进行化颗粒.
- 调查居住时间分布作为物质运输的指标.
- 采用双隔间模型来分析轴向运输和混合.
主要成果:
- 改变料速度和旋转速度调整颗粒器填充水平,影响运输速度和混合.
- 行星滚筒颗粒器的独特设计增强了加热表面与加工体积的比率.
- 两部分模型有效地反映了运输和混合动力之间的相互作用.
结论:
- PRMG是一种有前途的连续制造技术,用于制药应用.
- 了解居住时间分布是优化PRMG流程的关键.
- 与传统方法相比,PRMG在减少灰尘和消除干燥步骤方面提供了显著的优势.
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