基于桑/绿色粘土复合材料和花提取物的聚合物贴片作为治疗伤口的生物可持续药物
Carmen Laura Pérez Gutíerrez1,2, Alessandro Di Michele3, Cinzia Pagano1
1Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy.
Pharmaceutics
|August 26, 2023
概括
花贝提取物 (HSE) 在奇托桑绿色的粘土斑块促进皮肤细胞的生长,并抑制抗生素耐药的金黄色葡萄球菌. 这种新的伤口包裹为伤口愈合应用提供了一个有前途的天然替代品.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 皮肤病学 皮肤病学
背景情况:
- 子是一种丰富的农业废物,具有尚未开发的制药潜力.
- 由于抗生素耐药性增加,开发新型伤口愈合剂至关重要.
研究的目的:
- 调查子贝提取物 (HSE) 作为伤口愈合贴片的生物活性成分.
- 为了制定和表征含有HSE的奇托桑绿色粘土补丁.
主要方法:
- 使用酒化方法提取HSE.
- 补丁是通过造方法准备的,使用高度脱乙的奇托和绿色粘土.
- 在体外测试中评估了角质细胞的增殖和黄金葡萄球菌的抑制.
主要成果:
- 含有HSE的贴片刺激了角质细胞的生长,表明了伤口愈合的潜力.
- 补丁显著抑制了金黄色葡萄球菌的生长 (经过48小时后的Log CFU/mL为0.95对比8.85对照).
- 开发的补丁表现出适合实际应用的充分拉伸性能.
结论:
- 子贝提取物具有适用于伤口治疗的生物活性特性.
- 含有HSE的基托桑绿色粘土复合贴片是治疗伤口的有希望的配方.
- 开发的贴片显示出作为有效的抗微生物和再生性伤口包裹的潜力.
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