在便携式弹性体输液中安皮西林的稳定性:在门诊亲肠道抗菌疗法中迈出了一步
Lorena Rodríguez-Martínez1, Ana Castro-Balado1,2,3, Gonzalo Hermelo-Vidal1
1Clinical Pharmacology Group, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.
Pharmaceutics
|August 26, 2023
概括
使用弹性的门诊亲肠道抗菌疗法 (OPAT) 对复杂感染具有前景. 15 mg/mL的安培素度是稳定的OPAT当冷藏,然后在室温下24小时.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 药物输送系统 药物输送系统
背景情况:
- 门诊亲肠道抗菌疗法 (OPAT) 为复杂感染提供了长时间住院治疗的替代方案.
- 弹性体输液是OPAT的关键技术,但药物稳定性数据有限.
- 西林是一种常见的抗生素,用于治疗需要长时间治疗的严重感染.
研究的目的:
- 评估AMPICILLIN在elastomeric输液中的稳定性,在OPAT相关的各种储存和温度条件下.
- 为了确定在OPAT中使用安培的最佳度和条件.
- 为了告知安培在门诊机构的安全和有效应用.
主要方法:
- 在0.9%的化中对15 mg/mL和50 mg/mL的安皮西林的稳定性在弹性中进行了评估.
- 在冷藏和随后暴露于25°C和32°C后,对药物度进行了监测.
- 研究了冷却装置对高温稳定性的影响.
主要成果:
- 西林在15毫克/毫升的剂量保持稳定72小时冷藏,然后在25°C (冷却或不冷却) 24小时.
- 在32°C时,15mg/ml度在8小时内下降到90%以下.
- 50 mg/mL的安皮西林在冷藏后仅稳定24小时,不适合在室温下使用.
结论:
- 当冷藏并在25°C下在24小时内施用时,15 mg/mL的安皮西林度适合OPAT.
- 较高的温度 (32°C) 损害了弹性中的安皮西林稳定性.
- 调整输液量和速率以适应剂量需求对于在OPAT中使用15 mg/mL安培来说至关重要.
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