抗药物兼容性评价与儿科亲口营养添加剂的组合
Szymon Tomczak1, Maciej Chmielewski1, Jagoda Szkudlarek1
1Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka, 60-780 Poznań, Poland.
Pharmaceutics
|August 26, 2023
概括
抗药物,如丹塞,德克萨梅他和皮是兼容的儿科亲体营养添加剂 (PNAs). 这项研究证实了它们的稳定性,确保了有效的化疗副作用管理,而不会影响营养治疗.
科学领域:
- 临床药房 临床药房
- 制药科学 制药科学
- 瘤学 支持性护理 支持性护理
背景情况:
- 化疗诱导的恶心和吐 (CINV) 是患者报告的重大副作用,影响治疗的坚持和疗效.
- 抗emetic预防对于管理CINV和维持治疗方案至关重要.
- 与亲肠营养添加剂 (PNA) 同时使用抗药需要评估兼容性和稳定性.
研究的目的:
- 评估常见的抗药物与儿科亲口营养添加剂 (PNA) 的兼容性和稳定性.
- 评估在与各种儿科PNA联合使用时,Ondansetron,Dexamethasone和Hydrocortisone之间的潜在相互作用.
主要方法:
- 一项体外兼容性研究模拟了Y部位同时服用抗和儿科PNA的Y部位兼容性研究.
- 测试的PNA包括不同的氨基酸来源 (Primene®,Aminoplasmal Paed® 10%) 和脂质乳液 (Lipidem®,Clinoleic®,SMOFlipid®,Intralipid®).
- 评估的参数包括pH,度,度,泽塔潜力,最小可检测差异 (MDD) 和均性.
主要成果:
- 所有测试的儿科PNAs都在可接受的参数 (pH,度,度,泽塔潜力,MDD,同质性) 内的稳定性.
- 同时使用丹塞,德克萨米和皮对脂质乳液的稳定性没有产生负面影响.
- 在整个评估期内,抗药和PNA的测试组合始终兼容.
结论:
- 与各种儿科PNA联合使用的丹塞,德克萨米和皮的同时使用是化学兼容和稳定的.
- 这些发现支持在儿科瘤患者中安全地将抗治疗与营养支持相结合.
- 临床药剂师可以自信地管理这些药物的同时使用,优化患者护理和治疗结果.
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