通过使用纳米颗粒嵌入聚合物膜的方法,对阳性和阴性细菌进行压力动态消灭
Chan Chen1, Shubham Roy2,3, Jingjing Wang2,3
1Department of Clinical Laboratory, Shenzhen Baoan Hospital, The Second Affiliated Hospital of Shenzhen University, Shenzhen 518000, China.
Pharmaceutics
|August 26, 2023
概括
一种新的 piezodynamic 疗法,使用带有 bismuth ferrite 的聚合物膜,有效地根除了超过 99% 的大肠杆菌和 E. faecalis 细菌. 这种可重复使用的膜为对抗细菌感染提供了有希望的解决方案.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
背景情况:
- 抗生素耐药性和多药耐药性 (MDR) 对人类健康构成重大威胁.
- 动态抗菌疗法提供了替代治疗策略.
- 使用机械刺激的平动力学疗法是细菌感染治疗的新兴方法.
研究的目的:
- 开发和评估一种用于细菌根除的新型压力动力疗法.
- 为了利用带有酸活 bismuth 铁化的聚合物 (化-co-hexafluoropropylene) 聚合物膜来对抗细菌感染.
- 为了研究对格拉姆阳性 (E. faecalis) 和格拉姆阴性 (E. coli) 细菌的疗效.
主要方法:
- 一个独立的膜的制造,由含有比斯木铁的聚 ((维尼利丁化物-co-hexafluoropropylene)) 组成.
- 使用X射线衍射和扫描电子显微镜对膜结构和形态的表征.
- 通过福里埃变换红外光谱学评估压力活性,并使用软超声波 (~10 kHz) 进行细菌切除.
主要成果:
- 膜表现出显著的压力活性,FTIR证实了这一点.
- 超声波应用后30分钟内,E. coli和E. faecalis的根除率超过99%.
- 膜的固态和疏水性质允许成功循环重复使用,这是一个新的发现.
结论:
- 用发达的膜进行平动力疗法对阳性和阴性细菌都非常有效.
- 膜的可重复使用性质提供了一个可持续且具有成本效益的抗菌解决方案.
- 潜在的应用包括医疗保健系统,颜料工业和自洁材料.
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