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针对抗真菌治疗应用的牛乳荷载的等离子磁脂体

Mélanie Pereira^1,2, Ana Rita O Rodrigues^1,2, Leslie Amaral³

¹Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.

|August 26, 2023

概括

将牛乳酸 (bLf) 封装在等离子磁极体 (PMLs) 中可以增强其抗真菌活性. 这些新型纳米载体显示出有希望的潜力,用于向的BLF输送和真菌感染的有效治疗.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
菌类学菌类学是指菌类学.

背景情况:

牛乳酸 (bLf) 具有广泛的抗真菌特性,但容易降解.
响应刺激的配方可以增强bLf的生物活动和稳定性.
血磁极体 (PMLs) 是用于双重高温和药物输送的多功能纳米载体.

研究的目的:

开发和表征bLf载PMLs用于增强抗真菌疗法.
为了研究Saccharomyces cerevisiae中PMLs的内化机制.
为了评估bLf装载PML的抗真菌功效.

主要方法:

含有铁和黄金纳米粒子的PML的制备和表征.
将bLf加载到功能化的PML中.
对纳米粒子特性 (光学,磁性,结构) 和特定吸收率 (SAR) 的评估.
通过殖民地形成单位计数和使用光显微镜进行内部化研究来评估抗真菌活性.

主要成果:

PMLs已成功准备并装载了bLf.
纳米粒子属性得到证实,SAR表明过热的可能性.
在Saccharomyces cerevisiae中,PML的内部化是通过能量和温度依赖的内细胞分裂发生的.
带有bLf的PML表现出与自由bLf相比的抗真菌细胞毒性.

结论:

装有bLf的PML是有效的纳米载体,可以提供牛乳酸.
开发的PML显示出抗真菌治疗干预的巨大潜力.
bLf和PMLs的组合为对抗真菌感染提供了一个有希望的策略.

关键词:

抗真菌活动的抗真菌活性.牛乳酪蛋白是牛乳酪蛋白中的一种.细胞毒性细胞毒性双重高温症是因为双重高温症.塑的磁极型体

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