在mRNA-1273 SARS-CoV-2疫苗接种后发生的多炎的eosinophilic granulomatosis
Lucrezia Mencarelli1, Laura Moi2, Natacha Dewarrat3
1Division of Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne University, 1011 Lausanne, Switzerland.
Vaccines
|August 26, 2023
概括
在mRNA-1273疫苗接种后发生的严重的多炎 (EGPA) 埃索诺菲尔粒状瘤病例罕见. 虽然因果关系尚未被证明,但与免疫刺激的时间联系需要进一步调查疫苗后炎症疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 数以百万计的人接种了针对SARS-CoV-2的疫苗,很少有报道称疫苗接种后出现新的系统性炎症性疾病.
- 带有多炎的埃索诺菲尔粒状瘤 (EGPA) 是一种罕见的自身免疫性疾病,通常影响患有喘或鼻炎的成年人.
研究的目的:
- 描述mRNA-1273接种疫苗后发生的严重EGPA病例.
- 审查和分析与SARS-CoV-2 mRNA疫苗接种临时相关的EGPA报告病例.
主要方法:
- 一个年轻的喘妇女的病例报告,在接种疫苗后患有严重的多系统EGPA.
- 在SARS-CoV-2 mRNA疫苗接种后报告的EGPA病例的文献综述.
主要成果:
- 描述的病例涉及严重的EGPA与心脏和中枢神经系统的参与,再加上二次免疫血栓缩 (ITP).
- 所有审查的疫苗接种后EGPA病例发生在免疫接种14天内.
- 报道的疫苗接种后EGPA病例的发生率与预期的背景率一致.
结论:
- 观察到SARS-CoV-2mRNA疫苗接种和EGPA发作之间的时间关联,尽管因果关系尚未确立.
- 疫苗接种的免疫刺激在EGPA病变的背景下可能是有趣的.
- 疫苗接种后出现的炎症性疾病很少见,SARS-CoV-2 mRNA疫苗的好处超过了这些风险.
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