在意大利北部大规模接种COVID-19疫苗之前和之后,COPD相关的死亡率
Ugo Fedeli1, Veronica Casotto1, Claudio Barbiellini Amidei1
1Epidemiological Department, Azienda Zero-Veneto Region, 35131 Padua, Italy.
Vaccines
|August 26, 2023
概括
COVID-19大流行最初增加了慢性阻塞性肺病 (COPD) 死亡率,特别是当COVID-19是潜在原因时. 大规模接种疫苗的努力显著减少了COPD相关的死亡,特别是在老年人中.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在人口层面上,COVID-19大流行对慢性阻塞性肺病 (COPD) 死亡率的影响在很大程度上是未知的.
- 调查不同流行病波的COPD死亡率趋势以及疫苗接种的影响至关重要.
研究的目的:
- 评估COVID-19流行病对意大利COPD相关死亡率的影响.
- 分析COVID-19疫苗接种活动之前和之后的死亡率趋势,特别是在不同年龄组.
主要方法:
- 意大利维内托地区40岁以上居民的死亡证明分析 (2008-2021年).
- 对COPD的年龄标准化死亡率的计算提到.
- 使用通用估计方程 (GEE) 模型来估计与流行病相关的死亡率趋势,按年龄,并发病和死亡地点分层.
主要成果:
- 与2018-2019年平均水平相比,2020年COPD在14%的死亡证明中被提及.
- 2020年,所有群体的COPD年龄标准化死亡率都增加了;到2021年,老年人死亡率恢复到大流行前的水平,但40-79岁的人死亡率没有增加 (+6%).
- COVID-19是高达35%的COPD死亡的潜在原因,在峰值的流行浪潮期间;并发性糖尿病和高血压显示死亡率略有增加.
结论:
- 由于COVID-19的死亡,COPD的死亡率最初上升.
- 疫苗接种运动与COPD死亡率显著下降相关,特别是在老年人中.
- 大规模疫苗接种在缓解COPD相关死亡病例的流行病后期阶段起着至关重要的作用.
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