非洲猪瘟病毒-宿主和病毒-病毒蛋白相互作用的功能景观
Katarzyna Magdalena Dolata1, Gang Pei2, Christopher L Netherton3
1Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, Germany.
Viruses
|August 26, 2023
概括
了解非洲猪瘟病毒 (ASFV) 与宿主和病毒蛋白质的蛋白质相互作用是开发治疗方法的关键. 本综述汇编了ASFV互动组数据,以指导未来的抗病毒策略.
科学领域:
- 病毒学 病毒学
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 病毒复制取决于宿主细胞机械,蛋白质-蛋白质相互作用 (PPI) 介导关键步骤.
- 识别病毒宿主PPI为感染机制提供了洞察力,对于抗病毒策略的开发至关重要.
- 非洲猪瘟病毒 (ASFV) 是一种重要的猪病原体,对宿主和病毒点的了解很差,阻碍了疫苗和治疗的进展.
研究的目的:
- 系统地审查和汇编有关ASFV病毒宿主和病毒-病毒PPI的现有知识.
- 创建一个关于ASFV蛋白标,它们的相互作用机制和功能的全面数据集.
- 识别知识差距,并为ASFV交互原子研究提出未来研究方向.
主要方法:
- 文献综述和从专注于单个ASFV病毒蛋白的研究中收集数据.
- 对参与ASFV感染的实验性确定宿主和病毒蛋白点的分析.
- 收集有关已识别的PPI分子机制和生物功能的数据.
主要成果:
- 一个精心策划的ASFV宿主和ASFV病毒PPI数据集已经组装在一起.
- 该综述详细介绍了ASFV感染期间这些相互作用的分子机制和生物作用.
- 已经确定了关键的病毒蛋白和它们在宿主和病毒中的相互作用伙伴.
结论:
- 这项工作提供了ASFV互动组的系统概述.
- 汇编的数据突出了理解ASFV与宿主相互作用的关键知识差距.
- 未来的研究应该专注于填补这些差距,以推进ASFV疫苗和治疗开发.
相关概念视频
Viral Recombination
23.5K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.5K
Protein-protein Interfaces
12.5K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K
Protein-Protein Interfaces
3.8K
3.8K
Viral Structure
62.4K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
62.4K
Leaky Scanning
5.2K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.2K
Subviral Agents
41
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
41


