关键COVID-19患者肺部和全身炎症的分段化调节
Luciana Santiago1,2,3,4, Marcela Helena Gonçalves-Pereira3, Mariana Sousa Vieira3
1Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Viruses
|August 26, 2023
概括
危急的COVID-19患者表现出明显的肺部和血液炎症反应. 局部肺炎与生存有关,而全身炎症表明预后更差.
科学领域:
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
背景情况:
- 危急的COVID-19与改变的细胞因子简介有关.
- 不同的肺部和全身炎症过程发生,但对比研究有限.
研究的目的:
- 在重症COVID-19患者中比较肺部和全身细胞因子/化学因子概况.
- 调查这些个人资料与患者结果之间的关系.
主要方法:
- 细胞因子和化学因子水平测量在血和迷你支气管支气管洗 (迷你BAL).
- 样品采集在输管后48小时和5-8天内.
- 幸存者和非幸存者群体之间的比较.
主要成果:
- 在肺部和血液中观察到不同的炎症模式.
- 幸存者具有较高的肺细胞因子 (例如,IFN-γ,IL-2,IL-4);非幸存者具有较高的血液细胞因子 (例如,IL-6,CXCL8).
- 高的mini-BAL TNF/CXCL8与更好的氧化相关;高的血IFN-γ与更差的肺功能相关 (PaO2/FiO2比率).
结论:
- 局部肺炎具有保护性作用,并与危急COVID-19的生存有关.
- 系统性炎症是有害的,并与死亡率有关.
- 建议分别调节肺部和血液的炎症反应.
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