在住院患者中,乌尔索多西胆酸并不能改善COVID-19的结果
Francesca Colapietro1,2, Giovanni Angelotti1,3, Chiara Masetti2
1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy.
Viruses
|August 26, 2023
概括
乌尔索多西胆酸 (UDCA) 对COVID-19患者死亡率没有影响,但与减少对呼吸系统支持的需求有关. 对于SARS-CoV-2感染的UDCA的现实世界数据仍然有限.
科学领域:
- 肝病学和传染病的研究
- 胃肠病学 胃肠病学
- 内部医学 内部医学
背景情况:
- Ursodeoxycholic 酸 (UDCA) 已在体外证明对SARS-CoV-2的有效性,并对慢性肝病患者有好处.
- 关于UDCA对COVID-19结果的影响,现实世界的临床数据有限.
研究的目的:
- 评估UDCA对住院患者COVID-19结果的影响.
- 评估UDCA对死亡率和需要呼吸辅助 (CPAP) 的影响.
主要方法:
- 在2020年1月至2023年1月期间,对3847名因COVID-19住院的患者进行了回顾性分析.
- 57名UDCA患者和3790名对照患者之间的结局比较.
- 统计分析,以确定UDCA对死亡率和CPAP治疗的影响,并根据相关疾病进行调整.
主要成果:
- 在UDCA和对照组之间的总死亡率没有显著差异 (22.8%与21.3%,p=0.243).
- 在UDCA组中,CPAP治疗率明显较低 (OR=0.76,p<0.05).
- 在UDCA组中,肝病和疫苗接种率较高.
结论:
- 在住院COVID-19患者中,UDCA治疗与改善的生存率无关.
- 在COVID-19患者中,UDCA可能会减少对CPAP治疗的需求.
- 需要进一步的研究来证实UDCA在管理COVID-19中的作用,特别是在特定的患者子组中.
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