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在艾滋病毒感染者中使用多卢特格拉维尔和拉米武丁作为初始或交换疗法的现实生活经验
Maria Mazzitelli1, Lolita Sasset1, Samuele Gardin1
1Infectious and Tropical Diseases Unit, Padua University Hospital, 35128 Padua, Italy.
Viruses
|August 26, 2023
概括
多卢特格拉维尔和拉米武丁 (DTG/3TC) 对65岁以上艾滋病毒感染者 (PLWH) 的老年人来说是安全有效的. 这项长期研究表明,在这个人群中,持续的病毒抑制和没有负面的代谢变化.
科学领域:
- 老年医学 老年医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 杜洛特格拉维尔和拉米武丁 (DTG/3TC) 的有效性和安全性已在艾滋病毒感染者 (PLWH) 中得到证实.
- 对于老年PLWH (≥65岁) 的DTG/3TC存在有限的长期数据.
- 这项研究解决了在这个特定的人口群体中对现实世界数据的需求.
研究的目的:
- 评估DTG/3TC在65岁及以上艾滋病毒感染者中长期的安全性和有效性.
- 评估代谢,,免疫和心血管生物标志物的变化.
- 确定与病毒学失败和治疗中止相关的因素.
主要方法:
- 对112名年龄≥65.5岁的PLWH现实生活队列的回顾性分析.
- 从基线到最后的随访评估实验室和临床参数的评估.
- 用于参数变化分析的配对威尔科克森试验.
- 分析与病毒学失败 (VF) 和停止治疗相关的因素.
主要成果:
- 参与者的平均年龄为66岁,84.8%的人患有多病症,34.8%的人服用多种药物.
- 平均治疗持续时间为6年,在92.8%的个体中,持续的HIVRNA无法检测.
- 在代谢,,免疫或心血管生物标志物中没有观察到显著的变化.
- 停药率低 (7.1%),没有与VF或停药有显著关联的因素.
结论:
- 在长达5年的随访期间,DTG/3TC在老年PLWH (≥65) 中证明了安全性和有效性.
- 该疗法在代谢上是中性的,并且由于毒性或病毒学失败而导致的中止率很低.
- 这项研究为在艾滋病毒感染的老年人中使用DTG/3TC提供了关键的长期实践证据.
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