子和塔拉罗米切斯种类. 自20世纪90年代以来,狗身上出现的新兴病原体
Lorra Monpierre1,2, Nicolas Soetart3, Isabel Valsecchi2
1Unité de Mycologie-Parasitologie; Département Prévention, Diagnostic, Traitement des infections, Hôpitaux Universitaires Henri Mondor, Créteil, France.
Medical mycology
|August 26, 2023
概括
狗中由Penicillium和Talaromyces模具引起的罕见真菌感染的治疗具有挑战性. 这项研究强调了四个新的病例,强调了预后不佳以及需要对这些不常见的动物真菌病进行进一步研究.
科学领域:
- 兽医真菌学 兽医真菌学
- 动物传染病 在动物中的传染病
背景情况:
- 子和塔拉罗米塞斯物种是通常在环境中发现的菌菌.
- 这些真菌很少被认为是动物感染的致病原体,因此记录的病例很少出现.
- 了解这些感染的临床表现和结果对于兽医诊断和治疗至关重要.
研究的目的:
- 在四只狗中总结了已证明的Penicillium或Talaromyces感染的临床特征,治疗策略和结果.
- 为了促进这些菌感染在狗的有限的全球病例报告.
- 为了强调管理这些罕见感染的挑战.
主要方法:
- 一系列病例报告了四只被证实感染Penicillium或Talaromyces的狗.
- 组织病理学检查,以确定真菌元素 (素隔膜).
- 菌培养和内部转录间隔器 (ITS) 桑格测序用于物种识别.
主要成果:
- 两只狗出现了扩散感染,两只狗出现了局部形式.
- 组织病理学证实了真菌的存在,培养物确定了Tallaromyces georgiensis,Penicillium labradorum和Penicillium系列Raistrickiorum.
- 最初使用阿佐尔 (基托可纳,伊特拉可纳) 的治疗通常会随之复发,导致预后不佳.
结论:
- 狗的Penicillium和Talaromyces感染,虽然很少见,但可以呈现为传播或局部疾病.
- 用标准抗真菌剂治疗可能具有挑战性,复发风险高,结果差.
- 这些病例增加了有限的文献,表明这种感染在全球可能被低估了.
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