在慢性自发性疹中,IgE和C-反应蛋白与不同的微RNA和介素-31有关
Ozge Sevil Karstarli Bakay1, Betül Demir2, Demet Cicek2
1Department of Dermatology, Pamukkale University Faculty of Medicine, Denizli, Turkey.
Clinical and translational allergy
|August 26, 2023
概括
免疫球蛋白E (IgE) 和C反应蛋白 (CRP) 水平表明慢性自发性疹 (CSU) 的疾病活性. 显著的微RNA配置文件与这些生物标志物相关,可能表明自身免疫性CSU.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 分子生物学分子生物学
背景情况:
- 慢性自发性疹 (CSU) 是一种普遍且使人虚弱的疾病.
- 在CSU中免疫球蛋白E (IgE) 和C反应蛋白 (CRP) 的诊断实用性需要进一步描述.
- 在CSU中IgE,CRP和特定的microRNA (miRNA) 签名或IL-31 (IL-31) 之间的关系尚不清楚.
研究的目的:
- 研究IgE和CRP作为CSU中的生物标志物的临床相关性.
- 在CSU患者中探索IgE,CRP和特定miRNA配置文件 (miR-155,miR-221) 和IL-31水平之间的关联.
- 确定这些生物标志物是否可以区分疾病活动,并可能表明自身免疫参与.
主要方法:
- 在47名CSU患者和45名健康对照中测量了血清IgE和CRP水平.
- 用疹活动得分 (UAS7) 评估CSU疾病活性.
- 使用RT-PCR量化了miR-155和miR-221的表达,并通过ELISA测量了IL-31水平.
主要成果:
- 骨髓炎患者表现出较高的IgE和CRP水平,这与疾病活性相关.
- IgE水平与miR-155相关,而CRP水平与miR-221相关.
- 在CSU患者中,miR-155和miR-221显著过度表达,显示出高诊断精度.
- 升高的CRP和miR-221与增加的IgG抗TPO和IL-31水平有关.
结论:
- IgE和CRP作为评估CSU疾病活性的有价值的生物标志物,每个与不同的miRNA配置文件相关.
- 高水平的CRP和miR-221可能表明自身免疫性CSU,并强调IL-31在疾病发病过程中的潜在作用.
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