对于原发性卵巢缺陷妇女及其亲属的家庭规模
L E Verrilli1,2, K Allen-Brady3, E B Johnstone1
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Human reproduction (Oxford, England)
|August 26, 2023
概括
患有原发性卵巢缺陷 (POI) 的女性生育的孩子比对照组少,中位数少了一个孩子. 对于一些人来说,生育能力可能会保持到诊断为止,但诊断后的怀孕率仍然很低.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 初级卵巢缺陷 (POI) 影响生育年龄的女性,往往导致生育挑战.
- 虽然已知POI会影响生育能力,但受影响女性与对照女性的家庭规模的比较尚未确立.
- 了解家庭规模差异对于咨询和管理POI妇女至关重要.
研究的目的:
- 为了比较患有原发性卵巢缺陷 (POI) 的妇女生育的孩子数量与年龄相匹配的对照人数.
- 调查POI妇女及其亲属的生殖寿命的家庭规模.
主要方法:
- 追溯病例控制研究涉及393名POI妇女和393名年龄匹配的对照.
- 利用电子医疗记录和犹他州人口数据库进行家谱和出生证明数据 (1915-2020年).
- 使用曼-惠特尼U测试,比较POI病例,对照组及其亲属之间的儿童数量和母亲出生时的年龄.
主要成果:
- 与对照组 (中位数2) 相比,患有POI的妇女生育的孩子较少 (中位数1).
- 53.7%的POI女性有孩子,而对照女性的比例为67.7%.
- 没有观察到POI妇女亲属所生孩子数量的显著差异.
结论:
- 与对照组相比,患有POI的妇女生育的孩子数量较少,差异大约为每个妇女一个孩子.
- 在一些POI的妇女中,生育能力可能会维持到诊断为止 (诊断为≥25岁的二次无精通病).
- 亲戚生孩子的数量没有差异,这表明POI可能不能仅仅通过家庭规模来轻松预测.
相关概念视频
Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
Infertility in Females
348
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
348
Ovarian Cycle
1.3K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.3K
Ovaries
982
The ovaries are roughly the size of almonds and measure approximately 2 to 3 centimeters in length. These paired structures are situated within the pelvic region and are anchored by the mesovarium—a peritoneal extension that also connects them to the wider structure of the broad ligament. The support system extends to the suspensory ligament, housing blood and lymphatic vessels. In addition, the ovarian ligament tethers the ovaries to the uterus.
On the ovarian surface, a layer of...
On the ovarian surface, a layer of...
982
Folliculogenesis
861
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
861
Hormonal Control of the Ovarian Cycle
565
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
565


