毛囊冲洗增加了检索的卵细胞数量:一个随机对照试验
G T Lainas1, T G Lainas1, A A Makris1
1Eugonia IVF, Unit of Human Reproduction, Athens, Greece.
Human reproduction (Oxford, England)
|August 26, 2023
概括
与单次吸收相比,毛囊冲洗显著增加了检索的卵细胞数量,无论卵巢反应如何. 这种技术提高了卵细胞的产量,但也增加了检索时间.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 卵细胞检索技术 卵细胞检索技术
背景情况:
- 之前的元分析表明,卵泡冲洗并没有改善卵细胞产量或怀孕率.
- 在之前的研究中,研究设计可能由于异质性和程序差异而掩盖了卵泡冲洗的真实效果.
研究的目的:
- 为了评估卵泡冲洗在增加回收的积卵细胞复合体 (COCs) 的数量方面的疗效,与单次吸收相比.
- 评估卵泡冲洗对卵细胞恢复,成熟,受精和胚胎质量的影响.
主要方法:
- 一个前性的,单中心随机受控试验 (RCT) 涉及105名接受ICSI卵细胞采集的患者.
- 卵巢被随机分配到单次吸收或卵泡冲洗中,如果最初没有检测到COC,则冲洗最多5次.
- 主要结局是检索的COC数量;次要结局包括卵细胞恢复,成熟,受精率和第2天胚胎质量.
主要成果:
- 在所有卵巢反应组中,卵泡冲洗显著增加了与单次吸收相比检索的COC数量 (P < 0.001).
- 卵细胞检索率在卵泡冲 (88.9%) 和单次吸收 (45.5%) (P < 0.001) 之间明显高.
- 卵细胞成熟,受精率或优质胚胎率没有显著差异;然而,卵泡冲洗增加了卵细胞检索时间.
结论:
- 这项RCT表明,卵泡冲洗有效地增加了COC检索,独立于卵巢反应.
- 这些发现暗示毛囊冲洗可以优化卵细胞检索,尽管需要进一步研究标准化流量.
- 虽然提高了卵细胞产量,但与卵泡冲洗相关的过程时间增加值得考虑.
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