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根据当今的证据,脂蛋白是否在临床上可行? 答案是肯定的是的

Gary S Ma¹, Tommy T Chiou¹, Michael J Wilkinson²

¹Division of Cardiovascular Medicine, Department of Medicine, Cardiovascular Institute, UC San Diego Health, Sulpizio Cardiovascular Center, University of California San Diego, 9434 Medical Center Dr, MC 7241, La Jolla, CA, 92037, San Diego, USA.

Current cardiology reports

|August 26, 2023

概括

升高的脂蛋白 (Lp) 是一个关键的心血管疾病风险因素. 目前的指导方针和证据证实,Lp(a) 测试在临床上可用于风险分层和指导治疗.

科学领域:

心血管医学心血管医学
临床遗传学临床遗传学
生物化学生物化学

背景情况:

脂蛋白 (Lp) 被认为是各种心血管疾病 (CVD) 的独立风险因素.
了解Lp (a) 的作用对于有效的心血管疾病预防策略至关重要.

研究的目的:

审查不断发展的Lp (a) 测试和管理的共识指南.
根据当前的证据,评估Lp的临床可行性 (a) 意识和测试.

主要方法:

对基因研究 (GWAS,门德尔随机化) 的审查,这些研究确定了Lp(a) 和CVD之间的因果关系.
分析影响Lp (a) 水平的非向和向疗法的证据.
评估Lp (a) 测试风险分层和级联查.

主要成果:

升高的Lp (a) 与冠状动脉疾病和形大动脉膜疾病有因果关系.
Lp (a) 测试有助于风险分层,识别高风险的个体,可与异合家族性高胆固醇血症相比较,并促进级联查.
降低Lp(a) 的疗法 (例如,PCSK9抑制,非) 显示出降低了动脉样硬化心血管疾病 (ASCVD) 风险.

结论:

脂蛋白测试在临床上可用于识别高风险患者,用于初级和二级ASCVD预防.
血红蛋白 (Lp) 水平可以指导治疗强化,并告知血红蛋白 (Lp) 水平升高的家族查.
针对降低Lp (a) 的向疗法正在开发中,进一步提高其临床效用.

关键词:

动脉的疾病动脉疾病冠状动脉疾病是一种冠状动脉疾病.遗传学遗传学是一个脂蛋白 (a) 是一种蛋白质心肌梗塞的心脏病发作主要预防主要预防.

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