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Updated: Jul 18, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

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2 - 基酸的两个反体不同调节细胞毒性T细胞功能

Iosifina P Foskolou1, Pedro P Cunha2, Elena Sánchez-López3

  • 1Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Site, Cambridge CB2 3EG, UK; Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Solnavägen 9, 171 65 Solna, Sweden; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory Amsterdam University Medical Center, University of Amsterdam, 1066 CX Amsterdam, the Netherlands; Oncode Institute, 3521 AL Utrecht, the Netherlands.

Cell reports
|August 26, 2023
PubMed
概括

S-2-基酸盐 (S-2HG),但不是R-2HG,增强CD8+T细胞适应性和抗瘤活性. 这些发现突出了2HG反体在调节T细胞功能的独特作用.

关键词:
2 - 基氨酸二氧化.CD8+ T 细胞功能 CD8+ T 细胞功能CD8+ T 细胞的记忆体CP: 免疫学 免疫学收养细胞转移的收养细胞转移在合成代谢物上.

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