初级妄想感染的治疗方法:系统性审查
Justin Di Lu1, Ryan D Gotesman2, Shawn Varghese1
1Michael G DeGroote School of Medicine, Hamilton, ON, Canada.
JMIR dermatology
|August 26, 2023
概括
妄想感染,或Ekbom综合征,是一种罕见的疾病,患者认为他们被感染. 第一代抗精神病药物在治疗中表现出与第二代抗精神病药物相似的有效性.
科学领域:
- 精神病学是一个精神病学.
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 妄想性感染 (Ekbom综合征) 是一种罕见的精神疾病,其特点是对感染的固定妄想.
- 患者经常出现皮肤病症状,需要明确的治疗指南.
- 对初级妄想感染的最佳管理策略尚不清楚.
研究的目的:
- 系统地审查和描述初级妄想感染患者的治疗和管理.
- 分析基于现有病例系列的治疗疗效,剂量,坚持和副作用.
主要方法:
- 在主要数据库 (MEDLINE,Embase,PsycINFO,Cochrane) 进行系统的文献搜索.
- 数据提取和分析的重点是治疗细节,患者反应和不良事件.
- 包括15个病例系列,包括280名被诊断患有妄想感染的患者.
主要成果:
- 阿里皮普拉在一小部分患者中显示出最高的完全缓解率 (79%).
- 选择性血清素再吸收抑制剂 (SSRI) 在患有并发性焦虑或抑郁症的患者中显示出高疗效 (79%的完全缓解).
- 第一代和第二代抗精神病药物表现出可比的完全缓解率 (分别约为54%和48%).
结论:
- 第一代抗精神病药似乎与第二代抗精神病药对妄想感染一样有效.
- 对于患有并发性精神疾病的患者来说,SSRI可能有益.
- 较大的研究和随机对照试验对于确认药理疗法的疗效至关重要.
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