模拟和利用生物工程人类组织对抗宇宙辐射的影响
Daniel Naveed Tavakol1, Trevor R Nash1, Youngbin Kim1
1Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
Biomaterials
|August 26, 2023
概括
工程人体组织模型宇宙辐射损伤空间任务. 这个平台有助于了解辐射效应,并测试用于宇航员安全的辐射保护剂.
科学领域:
- 太空医学 太空医学
- 辐射生物学 辐射生物学
- 组织工程是组织工程.
背景情况:
- 太空辐射对长期太空飞往月球和火星的任务构成重大风险.
- 了解辐射损伤机制和安全门对于宇航员保护至关重要.
- 现有的动物模型不能完全复制宇航员的分子变化,需要先进的体外系统.
研究的目的:
- 开发和利用生物工程组织平台来研究个性化的辐射损伤.
- 评估模拟银河系宇宙射线对放射敏感人体组织的影响.
- 在工程组织模型中评估辐射保护剂的疗效.
主要方法:
- 开发了一个生物工程组织平台用于体外辐射损伤研究.
- 使用工程心脏组织 (eCT) 和工程骨髓 (eBM) 模型.
- 暴露在高剂量中子 (模拟银河系宇宙射线) 的组织,并分析基因表达,表型和功能.
主要成果:
- 确定了与电离辐射反应,炎症,氧化应激和矩阵重塑相关的关键基因表达变化.
- 在eCT中观察到一个早期的过度缩的表型,在eBM中观察到骨髓变异.
- 证明了平台在测试放射性保护剂中的实用性.
结论:
- 个性化工程的人体组织模型为深空旅行期间的辐射影响提供了宝贵的见解.
- 这些模型可以阐明辐射损伤机制,并促进对宇航员的保护措施的测试.
- 该平台对个性化辐射风险评估和缓解策略充满希望.
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