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LRRK2通过促进MFN2降解和异常的线粒体完整性来加剧损伤

Shun Zhang1, Subo Qian1, Hailong Liu1

  • 1Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.

Redox biology
|August 26, 2023
PubMed
概括

富含白的重复激酶2 (LRRK2) 下调保护通过稳定线粒体蛋白质,防止急性损伤 (AKI) 和纤维化. 抑制LRRK2可能为脏疾病提供治疗策略.

关键词:
急性损伤 (AKI) 是一种严重的损伤.慢性病 (CKD) 是一种慢性病.富含白氨酸的重复激酶2 (LRRK2)线粒体损伤会导致线粒体损伤.米托素2 (MFN2) 是一种靠近的管状细胞 (PTC)

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