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基于二元多元的混合细胞系统:有效的解决方案,改善生物素A的溶解

Jaspreet Kaur¹, Pankaj Singla², Inderpreet Kaur¹

¹Department of Chemistry, UGC-Center for Advanced Studies, Guru Nanak Dev University, Amritsar 143005, India.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

|August 26, 2023

概括

普鲁尼克斯的二元混合微粒显著增强了疏水药物生物氨酸A (BCA) 的溶解. P84-P123 (1:2) 混合菌根表现出优异的药物加载和受控释放,具有水性药物递送的潜力.

科学领域:

材料科学材料科学材料科学
制药科学制药科学
药物运输药物运输药物运输

背景情况:

生物素A (BCA) 是一种天然的疏水药物,由于溶解性差,其生物利用性有限.
多重体块共聚合物形成微粒,可以封装疏水化合物,但它们的效率各不相同.
二元混合微粒 (MMs) 可能与纯的Pluronic系统相比,提供更好的溶解能力.

研究的目的:

为了评估纯粹的Pluronics (P84,P123,F127) 和它们的二进制混合微粒对生物素A (BCA) 的溶解效率.
为了研究BCA与不同Pluronic细胞系统之间的相互作用.
从开发的配方中评估BCA的药物释放特征.

主要方法:

使用紫外线可见光谱光度学进行溶解研究.
确定纯微粒和混合微粒的临界微粒度 (CMC).
使用微分脉冲电压计 (DPV) 的相互作用分析.
使用动态光散射进行水力动力直径测量.
在体外药物释放研究.

主要成果:

二元混合 (P84-P123和F127-P123) 的CMC含量明显低于纯.
在P84-P123 (1:2) MMs (3.51 mg/mL) 和F127-P123 (1:2) MMs (2.94 mg/mL) 中,与纯Pluronic相比,观察到增强的BCA溶解性.
与纯P84.4相比,P84-P123 (1:2) MMs对BCA显示出更高的结合亲和力 (Ka = 2.60 × 10^5 M^-1) 与纯P84.
BCA 加载增加了P84-P123 (1:2) 微粒的水力动力直径.
与纯粹的Pluronics相比,MMs显示BCA的持续释放.

结论:

P84-P123 (1:2) 混合微粒是比纯的Pluronic和其他测试的MMs更好的生物素A溶解剂.
这些MMs的增强溶解和受控释放特性为开发对疏水性药物的先进药物递送系统具有重大潜力.
这项研究验证了二进制混合粒的使用,作为一种有效的策略,以改善可溶性差的药品的输送.

关键词:

不同脉冲电压测量差异脉冲电压测量在体外释放的体外释放.混合的米塞尔.普鲁罗尼克斯是什么意思?溶解化溶解化紫外线可见光谱学

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