轻微的身体异常可能与精神分裂症患者的治疗耐药性有关
Can Uğurpala1, Ertuğ Berberoğlu2, Utku Özkan3
1Vezirkopru State Hospital, Department of Psychiatry, Samsun, Turkey.
Asian journal of psychiatry
|August 26, 2023
概括
轻微的身体异常 (MPA) 可能表明精神分裂症 (TRS) 的治疗耐药性. 在TRS患者中观察到MPA得分较高,特别是在眼睛和口腔区域,这表明与治疗结果的潜在联系.
科学领域:
- 精神病学是一个精神病学.
- 医学遗传学 医学遗传学
- 临床心理学 临床心理学
背景情况:
- 精神分裂症是一种复杂的精神障碍,治疗反应各不相同.
- 轻微的身体异常 (MPA) 是与神经发育障碍相关的微妙身体特征.
- 在精神分裂症中MPA和治疗耐药性 (TRS) 之间的关系需要进一步调查.
研究的目的:
- 调查轻微的身体异常 (MPA) 与精神分裂症治疗耐药性 (TRS) 之间的联系.
- 为了确定与治疗耐药性相关的特定MPA模式或位置.
- 探索MPA评分和TRS症状严重程度之间的相关性.
主要方法:
- 研究对137名精神分裂症患者和100名健康对照进行了评估.
- 修改后的Waldrup MPA尺度被用于评估MPA的存在和严重程度.
- 为了进行比较分析,患者被分为耐治疗精神分裂症 (TRS) 和非TRS组.
主要成果:
- 与对照组相比,在精神分裂症组中发现13种特定的MPA项目更频繁.
- 与非TRS患者相比,TRS患者的MPA总得分明显高于非TRS患者.
- 眼睛和口腔区域的MPA在TRS组中更为普遍 (n=57).
- 在TRS患者中,总MPA评分与简要精神病评分扩展 (BPRS-E) 的总和积极症状评分呈正相关性.
结论:
- 轻微的身体异常可能是精神分裂症治疗耐药性的潜在指标或促成因素.
- 特定的MPA模式,特别是在面区域,可能与精神分裂症治疗结果较差有关.
- 需要进一步的研究来阐明连接MPA和TRS的潜在机制.
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