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Updated: Jul 1, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
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Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

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突变的亨廷丁在轴突中的毒性作用是由其富含proline的域介导的

Scott T Brady1,2, Nichole A Mesnard-Hoaglin1, Sarah Mays1,2

  • 1Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.

Brain : a journal of neurology
|August 26, 2023
PubMed
概括

亨廷顿病的毒性涉及突变型亨廷丁 (mHTT) 中的富含proline的域 (PRD),它破坏了轴突运输. 针对这种PRD为亨廷顿病的轴突病理提供了一个新的治疗策略.

关键词:
亨廷顿病就是亨廷顿病.在JNK3中,JNK3是最常见的.这是一个SH3绑定域名.轴轴运输是一种轴轴运输.狩猎 狩猎 狩猎 狩猎富含普罗林的域名 富含普罗林的域名

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