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Updated: Jul 18, 2025

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
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凝血蛋白-MPL受体复合体的结构是偏向性血液形成的蓝图

Naotaka Tsutsumi1, Zahra Masoumi2, Sophie C James2

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.

Cell
|August 26, 2023
PubMed
概括

血栓形成素 (TPO) 的结构揭示了它如何激活其受体,使其能够产生修改后的TPO变体. 这些变种可以选择性地刺激血小板的产生,同时保留造血干细胞,帮助血液学研究和移植.

关键词:
美国国家数据局时间表c-MPL 其他化电磁场血液形成连接体工程在 mTOR信号传输结构血栓形成素

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