在狼性炎中是否需要按协议进行脏活检?
Ioannis Parodis1, Gabriella Moroni2, Marta Calatroni2
1Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Medical Unit of Gastroenterology, Dermatology, and Rheumatology, Karolinska University Hospital, Stockholm, Sweden; Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Autoimmunity reviews
|August 26, 2023
概括
在狼性炎 (LN) 中重复脏活检有助于治疗决策和预测结果,特别是当临床和组织学反应不同时. 协调每条协议活检仍然是一个挑战.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 病理学 病理学 病理学
背景情况:
- 基线活检是狼性炎 (LN) 分类和分化参与的标准.
- 对于在LN中重复脏活检的指示进行了辩论,有些人赞成临床监测.
研究的目的:
- 探索性炎管理中重复脏活检的实用性和适用性.
- 讨论每协议活检与临床指示重复活检的作用.
主要方法:
- 关于狼性炎中脏活检的当前文献和临床实践的审查.
- 讨论临床和组织学反应之间的差异.
主要成果:
- 重复脏活检可以对评估治疗反应,调节治疗和预测长期结果有价值.
- 建议在固定的时间点 (如6个月,1到2年) 进行每协议活检,以评估诱导和维持治疗的疗效.
- 对于不完整的反应或区分活跃和慢性病变,也建议重复活检.
结论:
- 重复脏活检在复杂的狼性炎病例中是一个有用的工具,用于治疗评估和预测结果.
- 在LN管理中协调每协议活检的使用需要进一步考虑.
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