相关实验视频
Updated: Jul 18, 2025

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Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
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通过超临界泡制造的内植入物用于治疗视网膜疾病
Carlos Bendicho-Lavilla1, Iria Seoane-Viaño2, Víctor Santos-Rosales3
1Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, and Materials Institute iMATUS, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain; Paraquasil Group (GI-2109), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.
概括
这项研究引入了一种新的绿色制造方法,使用超临界二氧化碳泡来制造长期持久的视网膜内植入物,用于视网膜疾病. 这些植入物可提供多达四个月的药物释放控制,改善患者治疗.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 慢性视网膜疾病导致全球显著的视力损伤.
- 目前的治疗方法,如内注射,对患者来说是沉重的.
- 对于眼内疾病,需要持续的药物输送系统.
研究的目的:
- 开发一种绿色和可持续的方法来制造静脉内植入物.
- 为了创建基于PLGA的多孔植入物,具有可控药物释放特征.
- 评估这种技术对小分子和生物制剂的可行性.
主要方法:
- 使用绿色超临界二氧化碳 (scCO2) 发泡技术.
- 采用3D打印来创建PLGA植入物的定制模具.
- 多种压缩率以控制植入物毛孔性和药物释放.
- 装有德克萨米他的植入物,后来是贝瓦西祖马布.
主要成果:
- 成功制造了多孔的PLGA视窗内植入物.
- 达到了多达四个月的甲释放控制.
- 证明了该技术在生物药物输送 (贝瓦西祖马布) 中的潜力.
结论:
- 绿色scCO2发泡为内植入物生产提供了一个可持续的替代方案.
- 这种方法允许调节的药物释放配置文件.
- 该技术适用于敏感药物,并解决了视网膜疾病治疗的未满足需求.
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