胃运动和变形:对术前胃癌辐射疗法的影响
Margot Bleeker1, Maarten C C M Hulshof2, Arjan Bel1
1Department of Radiation Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands.
International journal of radiation oncology, biology, physics
|August 26, 2023
概括
放射治疗期间的胃运动和变形是显著的,需要更大的胃癌规划边际. 每日图像指导和适应性辐射疗法可以帮助减少这些边缘.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 胃肠道瘤学 胃肠道瘤学
背景情况:
- 准确的术前胃辐射治疗需要了解胃的运动.
- 信托标记和4D成像对于量化解剖变化至关重要.
研究的目的:
- 为了研究胃间和内断的运动和变形.
- 为图像引导的术前胃辐射疗法提供定量数据.
主要方法:
- 14名胃癌患者接受了信托标记.
- 使用4DCT和4DCBCT成像来追踪标记物位置.
- 量化了分断,呼吸和治疗前后的运动和变形.
主要成果:
- 间断标记物位移显示系统误差为1.6-8.8毫米,随机误差为2.2-8.2毫米.
- 患者之间呼吸运动幅度有显著差异 (中位数为5.2-20毫米).
- 呼吸运动 (10.9毫米) 超过了断片间运动 (8.9毫米),超过了前后运动 (3.6毫米).
结论:
- 显著的胃运动和变形需要更大的规划目标体积边缘在胃癌放射治疗.
- 每日图像指导和适应性辐射疗法可能会降低所需的边际.
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