中性细胞与淋巴细胞的比率和周围假肢关节感染:系统性审查和元分析
Maryam Salimi1, Joseph Albert Karam2, Matthew Willman3
1Bone and Joint Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
The Journal of arthroplasty
|August 26, 2023
概括
中性粒细胞与淋巴细胞的比率 (NLR) 是在关节置换手术后诊断周围假肢关节感染 (PJI) 的可靠标志物. 这一元分析证实了它在各种PJI类型和关节整形手术过程中的诊断效用.
科学领域:
- 整形外科 整形外科 整形外科
- 传染性疾病 传染性疾病
- 诊断生物标志物 诊断生物标志物
背景情况:
- 周围假肢关节感染 (PJI) 是全面关节整形术后的一个重大并发症.
- 中性粒细胞与淋巴细胞的比率 (NLR) 已成为PJI诊断的潜在生物标志物.
- 这项研究系统地审查和元分析了NLR在诊断PJI中的实用性.
研究的目的:
- 系统地审查和元分析NLR在PJI诊断中的实用性.
- 为了评估 PJI 的 NLR 的诊断准确性.
主要方法:
- 在PubMed,Scopus和Web of Science的系统文献搜索到2022年.
- 在PJI诊断中评估NLR的12项符合条件的研究的元分析.
- 根据PJI类型和关节整形类型进行子组分析.
主要成果:
- 与无菌松动相比,PJI患者的NLR水平显著更高 (SMD = 1.05).
- 在急性和慢性PJI,以及在全膝关节和关节整形术中,NLR显示出显著的升高.
- 聚合灵敏度为0.73,聚合特异性为0.75,诊断几率比为8.26.
结论:
- 中性粒细胞与淋巴细胞的比率 (NLR) 证明了围围假肢关节感染 (PJI) 的显著诊断价值.
- 在不同临床场景中,NLR作为可靠和可访问的生物标志物用于识别PJI.
- 这一元分析支持将NLR集成到PJI的诊断算法中.
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