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VMHdm/c^SF-1的神经回路通过交腺驱动器调节骨肌肉PGC1-α

Takuya Yoshida¹, Mina Fujitani², Scotlynn Farmer³

¹Department of Cellular and Integrative Physiology, Long School of Medicine, University of Texas Health San Antonio, San Antonio, USA; Department of Clinical Nutrition School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.

Molecular metabolism

|August 26, 2023

概括

中枢神经系统 (CNS) 的神经元调节骨肌肉的新陈代谢. 腹中中枢下丘脑中的类固醇因子-1 (SF-1) 神经元激活上腺,通过β-2上腺受体 (β2AdR) 增加上腺素并增强骨肌肉功能.

科学领域:

神经科学是一个神经科学.
代谢调节代谢调节代谢调节
骨肌肉生理学骨肌肉生理学

背景情况:

中枢神经系统 (CNS) 调节外周器官的新陈代谢,以适应新陈代谢挑战.
连接中枢神经系统与骨肌肉的神经通路尚未完全理解.
类固醇原因子-1 (SF-1) 表达神经元在中腹下丘脑 (VMHdm/c^{SF-1神经元) 对于与运动相关的代谢适应至关重要.}

研究的目的:

阐明VMHdm/c/SF-1神经元调节骨肌肉功能的机制.
为了确定参与中枢神经系统介导的骨肌肉适应的神经通路.

主要方法:

光遗传学被用来操纵小鼠中的VMHdm/c^{SF-1神经元.}
他们使用了基因工程小鼠和对交上腺活动的手术操纵.
测量了骨肌氧化酶增殖器激活受体马协活性剂1α (PGC-1α) 的mRNA水平.

主要成果:

对VMHdm/c^SF-1神经元的光遗传激活显著增加了骨肌肉PGC-1αmRNA水平.
交上腺活动和β-2上腺受体 (β2AdR) 对于这种效果至关重要.
上腺切除和β2AdR淘汰消除了由VMHdm/c^SF-1神经元介导的PGC-1α增加.
VMHdm/c^SF-1神经元的下游节点显示在增加上腺素和骨肌PGC-1α的功能冗余.

结论:

一个新的神经通路 (VMHdm/cSF-1神经元 → 下游节点 → 上腺 → 骨肌 β2AdR) 是增强骨肌功能的基础.
这一途径对于新陈代谢适应具有挑战性的环境至关重要.
这些发现揭示了一个关键的中枢神经系统-骨肌肉通信轴,用于代谢控制.

关键词:

下丘脑的下丘脑是什么意思骨架肌肉是一个骨肌肉.同情神经系统的同情神经系统.在VMH中,VMH是VMH.

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