耐炎症药物输送纳米系统用于治疗细菌诱导的败血症
Vincent O Nyandoro1, Calvin A Omolo2, Eman A Ismail3
1Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; Department of Pharmaceutical Chemistry and Pharmaceutics, School of Pharmacy, Kabarak University, Nakuru, Kenya.
International journal of pharmaceutics
|August 26, 2023
概括
耐炎症纳米系统为败血症治疗提供有针对性的药物输送,克服了抗菌素耐药性等挑战,并提高了治疗潜力. 这些先进的系统对败血症微环境做出反应,以提高有效性.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 败血症是一种危及生命的疾病,全球死亡率高,由抗菌素耐药性和有限的常规治疗复杂化.
- 药物输送纳米系统显示出克服败血症治疗挑战的希望.
- 耐炎性纳米系统特别有趣,因为它们有针对性和可控的有效载荷释放.
研究的目的:
- 审查炎症响应药物输送纳米系统用于败血症治疗的最新进展.
- 讨论基于败血症微环境特征的设计原则.
- 评估这些纳米系统的治疗潜力和局限性.
主要方法:
- 对炎症反应性纳米系统治疗败血症的文献进行系统审查.
- 将纳米系统分为五个类别:受体向,pH响应,氧化还原响应,酶响应和多响应.
- 聚合物,纳米载体的分析,表征,加载的活性物质,药物释放和治疗疗效.
主要成果:
- 纳米系统利用败血症微环境特征,如酸性pH值,高调的受体,过度表达的酶和氧化应激.
- 在临床前研究中,各种响应性纳米系统证明了药物释放的增强和治疗疗效.
- 总结了主要发现的表格和图表,突出了优势和局限性.
结论:
- 耐炎症纳米系统为败血症治疗提供了卓越的治疗潜力.
- 需要进一步的研究来应对挑战,并探索临床翻译的未来前景.
- 这些纳米系统代表了改善败血症管理的有希望的途径.
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