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宫内器械发起者的头发皮质醇度变化:一个前性队列研究
Nora Doty1, Ethan Beckley2, Bharti Garg3
1Department of Obstetrics and Gynecology, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, United States.
Contraception
|August 26, 2023
概括
莱沃诺格斯特勒子宫内置器 (LNG 52 mg IUD) 和铜 IUD (CuT380 IUD) 在毛皮质醇水平上没有显著差异. 两种IUD类型都没有对情绪产生不利影响,而LNG IUD显示出有利的心理健康的趋势.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 心理神经内分泌学心理学
背景情况:
- 之前的研究表明,在使用莱沃诺格斯特勒52毫克宫内器械 (LNG52毫克宫内器械) 的女性中,头发皮质醇度升高,这是一个压力标志物.
- 下垂体-垂体-上腺 (HPA) 轴的激活是激素避孕研究中一个关键的兴趣领域.
研究的目的:
- 为了比较使用铜IUD (CuT380 IUD) 和levonorgestrel子宫内装置 (LNG 52 mg IUD) 的妇女之间的头发皮质醇度和心理健康状况的变化.
- 为了研究不同类型的IUD对HPA轴活动和情绪的潜在影响.
主要方法:
- 预期招募健康妇女开始使用LNG 52 mg IUD或CuT380 IUD.
- 在基线,6个月和12个月收集头发和血液样本,并进行心理测量评估 (PHQ-9,PANAS,PWBI).
- 使用液体染色学测量头发皮质醇 - - 双重质谱法测量,并对组间的变化进行统计比较.
主要成果:
- 在6个月后,在LNG 52 mg IUD和CuT380 IUD组之间没有观察到毛皮醇度平均变化的显著差异.
- 心理测量库存结果在两组都保持在正常范围内.
- 在LNG 52mg IUD使用者中,随着时间的推移,发现了更有利的心理变化趋势.
结论:
- 开始使用LNG 52 mg IUD或CuT380 IUD都没有导致头发皮质醇度的临床显著差异.
- 荷尔蒙IUD,特别是LNG 52mg IUD,似乎不会增加皮质醇度或对压力反应产生负面影响.
- 心理测量数据表明,与LNG 52 mg IUD相关的情绪不良影响,为其使用提供了保证.
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