外在和内在的亚托皮性皮肤炎之间的肠道微生物群的差异性变化
Xiaochun Liu1, Jing Xu2, Zhifeng Wang3
1Department of Allergy and Rheumatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China.
Journal of autoimmunity
|August 26, 2023
概括
这项研究将肠道微生物组成和L-histidine代谢与在亚托皮性皮炎 (AD) 中免疫球蛋白E (IgE) 水平升高联系起来. 环境卫生也影响了AD的发生和IgE水平,突出了复杂的相互作用.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
- 皮肤病学 皮肤病学
背景情况:
- 免疫球蛋白E (IgE) 的升高是阿托皮性皮肤炎 (AD) 的标志.
- 人们已经认识到肠道微生物组在阿尔茨海默氏症发病过程中的作用,但其与IgE水平的具体关系尚不清楚.
- 环境因素,如卫生,可能会影响AD和免疫反应.
研究的目的:
- 为了研究肠道微生物组成和阿托皮性皮肤炎患者的IgE水平之间的关联.
- 探索环境卫生,AD和IgE之间的关系.
- 确定与AD和IgE相关的特定微生物和代谢途径.
主要方法:
- 对250名阿尔茨海默病患者和138名健康志愿者环境暴露的分析.
- 从68名阿尔茨海默病患者和77名健康对照人群中对肠道微生物群的元基因组测序.
- 在AD患者和对照者之间比较微生物组成和功能途径,考虑外部和内在的AD亚型.
主要成果:
- 与健康对照人群相比,在AD患者中观察到独特的肠道微生物群组成.
- 在健康对照群中,L-histidine降解途径得到了丰富,而在AD患者中,L-histidine生物合成途径得到了丰富.
- 特定的微生物和功能途径在外部与内在AD中显示了差异性的丰富模式,与IgE水平和环境因素相关.
结论:
- 皮炎中IgE水平升高与特定的肠道微生物及其代谢功能有关,特别是L-histidine代谢.
- 环境卫生水平与AD发生率和IgE水平相关,表明环境,肠道微生物群和免疫系统之间存在复杂的相互作用.
- 肠道微生物群的组成和功能代表了在阿托皮性皮肤炎中管理IgE水平的潜在治疗标.
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