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开发和基准测试扩散磁共振成像分析,用于整合到辐射治疗规划中

Andrew Elliott¹, Emma Villemoes², Maguy Farhat¹

¹Department Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

Medical physics

|August 26, 2023

概括

这项研究将量化成像分析作为放射治疗计划的基准. 先进的多参数MRI工具显示可重现的表面扩散系数 (ADC) 和分数异构 (FA) 地图生成,符合临床整合标准.

科学领域:

辐射疗法辐射疗法
医疗成像医学成像
量化MRI是指数量化的MRI.

背景情况:

先进的多参数MRI,包括扩散加权成像 (DWI) 和扩散张力成像 (DTI),显示了放射治疗 (RT) 治疗规划的希望.
标准化定量成像分析,特别是明显扩散系数 (ADC) 和分数异构 (FA) 地图生成,对于临床整合至关重要.

研究的目的:

用商业处理计划系统 (TPS) 中的集成工具对已建立的方法进行ADC和FA参数图的生成比较.
评估用于RT规划的定量成像分析的准确性和可重复性.

主要方法:

使用了三个软件包:一个商业的TPS工具,FMRIB软件库 (FSL) 和一个内部开发的工具.
从35名受试者中生成了ADC和FA图,并通过减去图像并分析差异的标准偏差进行比较.
对ADC的量化成像生物标志物联盟 (QIBA) 协议和FA的已发表文献进行了复制性评估.

主要成果:

这三种方法生成的ADC图之间的差异不到2%,符合QIBA的3.6%的要求.
在FA图中的差异一般低于0.02,明显低于健康大脑物质中观察到的变化.
控制台生成的ADC和FA图的稳定性取决于正确的缩放因子;当正确应用时,差异处于QIBA指南范围内.

结论:

由经过测试的商业TPS产生的ADC和FA指标的定量可复制性与内部和已建立的基准工具可比.
商业TPS中的综合方法促进了扩散成像在RT规划工作流程中的临床实用性.

关键词:

看似的扩散系数.分数异构的分数异构.辐射处理计划辐射处理计划

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