在完整的细胞还原和高温腹腔内化学疗法后,尾癌的复发模式
Andrei Nikiforchin1, Armando Sardi2, Mary Caitlin King1
1Surgical Oncology, The Institute for Cancer Care, Mercy Medical Center, Baltimore, MD, USA.
Annals of surgical oncology
|August 26, 2023
概括
内复发 (IPR) 是尾癌 (AC) 在超热内化疗 (CRS/HIPEC) 的细胞还原性手术后所有级别中最常见的尾癌 (AC) 模式. 与其他模式相比,IPR还显示了较长的复发后生存时间.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 在用高热性腹腔内化疗 (CRS/HIPEC) 进行的细胞还原性手术后,尾癌 (AC) 复发模式尚不清楚.
- 现有假设表明低级 (LG) AC在腹膜内复发 (IPR),而高级 (HG) AC在腹膜内和外复发 (EPR).
研究的目的:
- 在CRS/HIPEC之后,研究和比较各种尾癌组织学中的复发模式 (IPR,EPR,组合).
- 评估复发模式对复发后生存的影响.
主要方法:
- 在1998-2022年期间,对432名接受完整CRS/HIPEC (CC-0/1) 的患者进行了回顾性队列研究.
- 通过AC组织学分层的复发模式 (IPR,EPR,组合) 的分析:LG,HG,高度与结号环细胞 (SRC) 和杯状细胞癌 (GCC).
- 平均随访时间为78个月;评估中位时间到复发 (MTR) 和复发后的存活率.
主要成果:
- 总体而言,34%的患者经历了复发. 在所有组织学 (16%-36%) 中,IPR是主要的模式,以后的MTR (21个月).
- EPR发生的频率较低 (3%-22%),MTR较早 (11个月). 在0%-8%的患者中观察到联合复发.
- 与EPR (13个月) 和联合复发 (18个月) 相比,IPR (36个月) 后的中位数复发后存活时间明显长 (p < 0.01).
结论:
- 内复发 (IPR) 是完整的CRS/HIPEC后所有尾癌组织学的主要模式.
- IPR发生较晚,并且与复发后的生存时间较长有关.
- 了解这些复发模式对于优化尾癌的随访和复发后管理策略至关重要.
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