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睡眠启动的客观和主观测量与青少年的DNA甲基化有着不同的关联

Michael Larsen¹, Fan He², Yuka Imamura Kawasawa³

¹Sleep Research and Treatment Center, Department of Psychiatry & Behavioral Health, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.

Clinical epigenetics

|August 26, 2023

概括

青春期改变了睡眠时间,与睡眠启动相关的基因发生了表观遗传变化. 这些DNA甲基化模式可能是预防失眠等睡眠障碍的目标.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
睡眠科学睡眠科学
时间生物学时间生物学

背景情况:

青春期会导致昼夜睡眠时间的变化,导致睡眠开始时间延迟 (SOT) 和睡眠开始延迟 (SOL).
全基因组关联研究 (GWAS) 已经确定了与睡眠表型相关的基因,但生理节律的表观遗传调节也至关重要.

研究的目的:

调查与青春期睡眠开始变化相关的表观遗传生物标志物.
探索DNA甲基化和青少年睡眠启动表型之间的联系.

主要方法:

在主观,动图 (ACT) 和多睡眠 (PSG) 睡眠测量中对DNA甲基化进行全基因分析.
基于GWAS的分析,以确定与睡眠启动相关的相关基因.

主要成果:

在1818个基因中发现了差异性DNA甲基化,跨越了睡眠启动措施.
通过GWAS信息分析确定了67个基因,其中特定的基因与睡觉时间,SOL和SOT有关.
一个基因SMG1P2显示了与主观,ACT和PSG测量的SOL相关的甲基化位点.

结论:

青少年睡眠启动与以前涉及成年睡眠GWAS的基因DNA甲基化发生变化有关.
在与昼夜调节,心脏代谢和神经精神疾病相关的基因中,在习惯性睡眠参数和DNA甲基化之间发现了表观遗传联系.
经验证的表观遗传部位可以作为早期检测和预防失眠和延迟睡眠阶段等睡眠障碍的目标.

关键词:

睡觉时间睡觉时间通过DNA甲基化.表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.睡眠启动睡眠启动睡眠延迟时间睡眠延迟时间

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