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Updated: May 30, 2026

Production, Crystallization and Structure Determination of C. difficile PPEP-1 via Microseeding and Zinc-SAD
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在肠道细胞中阻断Clostridioides difficile毒素A的8-mer的设计

Sudeep Sarma1, Carly M Catella1, Ellyce T San Pedro2

  • 1Department of Chemical Engineering, North Carolina State University, Raleigh, NC, 27695-7905, USA.

Communications biology
|August 26, 2023
PubMed
概括

研究人员开发了一种抑制剂SA1,用于阻止Clostridioides difficile毒素A. 这种可以通过向大肠来预防和治疗C. difficile感染.

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Bacterial Toxins01:12

Bacterial Toxins

Bacterial toxins are sophisticated virulence factors that enable pathogenic bacteria to interact with, invade, and damage host tissues. These toxins fall broadly into two types: protein exotoxins, which are secreted into the environment and target specific host receptors, and lipopolysaccharide endotoxins, which are structural components of the bacterial outer membrane released primarily during bacterial lysis or membrane shedding. Exotoxins generally act more selectively, binding to cell...